Journal
LAB ON A CHIP
Volume 10, Issue 7, Pages 894-898Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b916975j
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Funding
- NANO-Systems Institute National Core Research Center (NSI-NCRC)
- KOSEF [20090079103]
- MKE
- National Research Foundation of Korea [2009-0081999]
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We developed a carbon nanotube (CNT)-based biosensor system-on-a-chip (SoC) for the detection of a neurotransmitter. Here, 64 CNT-based sensors were integrated with silicon-based signal processing circuits in a single chip, which was made possible by combining several technological breakthroughs such as efficient signal processing, uniform CNT networks, and biocompatible functionalization of CNT-based sensors. The chip was utilized to detect glutamate, a neurotransmitter, where ammonia, a byproduct of the enzymatic reaction of glutamate and glutamate oxidase on CNT-based sensors, modulated the conductance signals to the CNT-based sensors. This is a major technological advancement in the integration of CNT-based sensors with microelectronics, and this chip can be readily integrated with larger scale lab-on-a-chip (LoC) systems for various applications such as LoC systems for neural networks.
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