Journal
LAB ON A CHIP
Volume 10, Issue 20, Pages 2655-2658Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0lc00068j
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Funding
- Australian Research Council (ARC) [DP0985502, 0774647]
- National Health and Medical Research Council (NHMRC) [569726]
- Queensland State Government
- The University of Queensland
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Minimally invasive biosensors are of great interest for rapid detection of disease biomarkers for diagnostic screening at the point-of-care. Here we introduce a device which extracts disease-specific biomarkers directly from the upper dermis, without the needle and syringe or resource-intensive blood processing. Using antigen-specific antibodies raised in mice as a model system, we confirm the analytical specificity and sensitivity of the antibody capture and extraction in comparison to the conventional methods based on needle/syringe blood draw followed by processing and antigen-specific ELISAs.
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