Journal
LAB ON A CHIP
Volume 10, Issue 23, Pages 3296-3299Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0lc00154f
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Funding
- Ministry of Education, Science and Technology [R01-2008-000-11260-0, A062254, 2009-0082087]
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Antibiotic resistance of biofilms is a growing public health concern due to overuse and improper use of antibiotics. Thus, determining an effective minimal concentration of antibiotics to eradicate bacterial biofilms is crucial. Here we present a simple, novel one-pot assay for the analysis of antibiotic susceptibility of bacterial biofilms using a microfluidics system where continuous concentration gradients of antibiotics are generated. The results of minimal biofilm eradication concentration (MBEC) clearly confirm that the concentration required to eradicate biofilm-grown Pseudomonas aeruginosa is higher than the minimal inhibitory concentration (MIC) that has been widely used to determine the lowest concentration of antibiotics against planktonically grown bacteria.
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