Journal
LAB ON A CHIP
Volume 9, Issue 23, Pages 3433-3436Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b912646e
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Funding
- European Commission
- Biodiagnostics [NMP4-CT2005-017002]
- Kristina Stenborg foundation
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We demonstrate ElectroWetting-On-Dielectric (EWOD) transport and SQUID gradiometer detection of magnetic nanoparticles (MNPs) suspended in a 2 mu l de-ionized water droplet. This proof-of-concept methodology constitutes the first development step towards a highly sensitive magnetic immunoassay platform with SQUID readout and droplet-based sample handling. Magnetic AC-susceptibility measurements were performed on MNPs with a hydrodynamic diameter of 100 nm using a high-Tc dc Superconducting Quantum Interference Device (SQUID) gradiometer as detector. We observed that the signal amplitude per unit volume is 2.5 times higher for a 2 ml sample droplet compared to a 30 ml sample volume.
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