Journal
LAB ON A CHIP
Volume 9, Issue 13, Pages 1836-1839Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b901327j
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Funding
- Korea Science and Engineering Foundation (KOSEF)
- Korea government (MEST) [R0A-2008-000-20078-0]
- National Research Foundation of Korea [과C6A1904, R0A-2008-000-20078-0, 2008-0060009] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A proof-of-concept study was reported on analysis of antigen antibody recognition based on resonant Rayleigh scattering response of single Au nanoparticles in an imaging chamber. As benefited by a traditional dark-field microscope and a spectrograph, individual Au nanoparticles (30 nm) were observed with high signal-to-noise ratio and they were effectively utilized to monitor changes in refractive index induced by specific binding of the adsorbates. Using PSA antigen as a model, a LSPR lambda(max) shift of about 2.85 nm was recorded for a molecular binding corresponding to 0.1 pg ml(-1) of the protein biomarker. This result successfully demonstrates a non-labeling detection system for proteins as well as thousands of different chemical or biological species, and it possesses a great potential as a sensitive, on-chip and multiplexing detection.
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