Journal
LAB ON A CHIP
Volume 9, Issue 2, Pages 239-243Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b812067f
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Funding
- Micro/Nano Fluidics Fundamentals Focus (MF3) [HR0011-06-10050]
- Korea Research Foundation Grant funded by the Korean Government (MOEHRD) [KRF-2006-D00017, KRF-2006-D00041]
- Integrated Confocal Nanofluidic SERS for Proteomics) [08K1501-02300]
- Center for Nanostructured Materials Technology under 21st Century Frontier R&D Programs of the Ministry of Science and Technology, Korea
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In this paper, signal amplifications of surface-enhanced Raman scattering (SERS) are realized by an optofluidic compact disc (CD)-based preconcentration method for effective label-free environmental and biomolecular detections. The preconcentration of target molecules is accomplished through the accumulation of adsorbed molecules on SERS-active sites by repeating a 'filling-drying' cycle of the assay solution in the optofluidic CD platform. After 30 cycles, the clear and high SERS signal of rhodamine 6G of 1 nM is readily detected. In addition to the preconcentration-based signal amplification by the optofluidic SERS system on the CD platform, we introduce a controlled precipitation of gold nanoparticles by CuSO4 for SERS substrates. This method provides high-throughput, high-sensitive and large-area uniform SERS substrates on the optofluidic CD platform. The uniform SERS signals from different positions in spots of 3 mm 2 on the different CDs gives us confidence in the reliability and stability of our SERS substrates.
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