Journal
LAB ON A CHIP
Volume 9, Issue 14, Pages 2021-2025Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b902986a
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Funding
- Australian Research Council (ARC)
- Merit Allocation Scheme on the APAC National Facility at the ANU
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An aromatic triarylpyridine chromophore promotes p-stacking interactions with the terminal G-tetrad in quadruplex DNA, stabilizing the structure and presenting a pathway towards cancer treatment by inhibition of telomerase. An interesting parent compound in this class is the dimethylamino functionalised 4'-aryl-2,6-bis(4-aminophenyl)pyridine. However, access to this compound using traditional batch synthetic methodology is limited, due to thermodynamic and kinetic constraints. A novel approach to the synthesis of this compound has been developed, involving dynamic thin films, overcoming a series of competing reactions, effectively controlling chemical reactivity and selectivity.
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