Journal
LAB ON A CHIP
Volume 9, Issue 1, Pages 50-55Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b812812j
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Funding
- National Institutes of Health [R01 GM072512]
- National Science Council, Taiwan [NSC 96-2811-E-002-054]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM072512] Funding Source: NIH RePORTER
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A robust and low dead volume world-to-chip interface for thermoplastic microfluidics has been developed. The high pressure fluidic port employs a stainless steel needle inserted into a mating hole aligned to an embedded microchannel, with an interference fit used to increase pressure resistance. Alternately, a self-tapping threaded needle screwed into a mating hole is also demonstrated. In both cases, the flat bottom needle ports seat directly against the microchannel substrate, ensuring low interfacial dead volumes. Low dispersion is observed for dye bands passing the interfaces. The needle ports offer sufficient pull-out forces for applications such as liquid chromatography that require high internal fluid pressures, with the epoxy-free interfaces compatible with internal microchannel pressures above 40 MPa.
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