Journal
LAB ON A CHIP
Volume 9, Issue 14, Pages 2016-2020Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b821247c
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Funding
- National Cancer Institute [5U54 CA119347]
- US Army Research Office [DAAD19-03-D-0004]
- Jean Perkins Foundation
- NATIONAL CANCER INSTITUTE [U54CA119347] Funding Source: NIH RePORTER
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We report herein on a self-powered, self-contained microfluidic-based chip designed to separate plasma from whole blood, and then execute an assay of a multiplexed panel of plasma biomarker proteins. The power source is based upon a chemical reaction that is catalytically triggered by the push of a button on the chip. We demonstrate assays of a dozen blood-based protein biomarkers using this automated, self-contained device. This platform can potentially permit high throughput, accurate, multiplexed blood diagnostic measurements in remote locations and by minimally trained individuals.
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