Journal
LAB ON A CHIP
Volume 9, Issue 13, Pages 1951-1956Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b902124h
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Funding
- Washington State's Life Sciences Discovery Fund (LSDF)
- National Institutes of Health [EB005197]
- Keck Foundation
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB005197] Funding Source: NIH RePORTER
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We recently reported a new UV-curable polyurethane-methacrylate (PUMA) resin that has excellent qualities as a disposable microfluidic substrate for clinical diagnostic applications. This article discusses strategies to improve the production yield of PUMA chips that contain dense and high-aspect-ratio features, which presents unique challenges in demolding and bonding steps. These fabrication improvements were deployed to produce a microfiltration device that contained closely spaced and high-aspect-ratio columns, suitable for retaining and concentrating cells or beads from a highly diluted suspension.
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