Journal
LAB ON A CHIP
Volume 9, Issue 9, Pages 1282-1285Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b900753a
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Funding
- DARPA [N66001-02-C-8039]
- NSF [BES 0428090]
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We have developed a novel, microfabricated, stand-alone microfluidic device that can efficiently sort and concentrate (bio-)analyte molecules by using kinesin motors and microtubules as a chemo-mechanical transduction machine. The device removes hundreds of targeted molecules per second from an analyte stream by translocating functionalized microtubules with kinesin across the stream and concentrating them at a horseshoe-shaped collector. Target biomolecule concentrations increase up to three orders of magnitude within one hour of operation.
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