Journal
LAB ON A CHIP
Volume 8, Issue 8, Pages 1262-1264Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b805456h
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Funding
- NIBIB [P41 EB002503]
- HFSP [RGPOO04/2005-CI02]
- NSF [DMR-0602684, DBI-0649865]
- Harvard MRSEC [DMR-0213805]
- NIH [1F32EB007901]
- American Cancer Society [PF-07-237-01-CCE]
- Deutsche Forschungsgemeinschaft [KO 3572/1]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [820484] Funding Source: National Science Foundation
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Encapsulation of cells within picolitre-size monodisperse drops provides new means to perform quantitative biological studies on a single-cell basis for large cell populations. Variability in the number of cells per drop due to stochastic cell loading is a major barrier to these techniques. We overcome this limitation by evenly spacing cells as they travel within a high aspect-ratio microchannel; cells enter the drop generator with the frequency of drop formation.
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