Journal
LAB ON A CHIP
Volume 8, Issue 12, Pages 2151-2156Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b812443d
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Funding
- Canadian Institutes of Health Research New Emerging Team Grant
- Natural Sciences and Engineering Research Council of Canada, Western Economic Diversification
- Canadian Foundation for Innovation
- Alberta Ingenuity Fund
- Canadian Institute for Photonic Innovations
- Informatics Circle of Research Excellence
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Fluorescence in situ hybridization (FISH) is a powerful technique for probing the genetic content of individual cells at the chromosomal scale. Conventional FISH techniques provide a sensitive diagnostic tool for the detection of chromosomal alterations on a cell-by-cell basis; however, the cost-per-test in terms of reagent and highly qualified labour has prevented its wide-spread utilization in clinical settings. Here, we address the inefficient use of labour with the first integrated and automated on-chip FISH implementation, one that requires only minutes of setup time from the technician. Our microfluidic chip has lowered the reagent use by 20-fold, decreased the labour time by 10-fold, and substantially reduced the amount of support equipment needed. We believe this cost-effective platform will make sensitive FISH techniques more accessible for routine clinical usage.
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