Journal
LAB ON A CHIP
Volume 8, Issue 12, Pages 2113-2120Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b811169c
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Funding
- DARPA [AF F30602-00-1-0569]
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This paper presents the development of an easy-to-handle and disposable clinical diagnostic lab-on-achip using fully integrated plastic microfluidic components, which has the sampling/identifying capability to make fast and reliable measurements of metabolic parameters from human whole blood. A smart and functional lab-on-a-chip cartridge, which incorporates a full on-chip auto-calibration function for in the field applications, has been developed, and then fully characterized using a portable analyzer (3(1/4)'' x 5 '' x 1 '') with multi-analyte detection capability. In addition, several new approaches in realizing smart and functional lab-on-a-chips on polymer have been adopted, which include the pinch valve for automatic fluidic sealing, a by-pass channel as the sampling indicator, and a robust connector design for long analyzer lifetimes. Metabolic parameters such as glucose, lactate, and partial oxygen from human whole blood have been successfully measured using the functional polymer lab-on-a-chips and the portable analyzer developed in this work.
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