Journal
KOREAN JOURNAL OF CHEMICAL ENGINEERING
Volume 31, Issue 6, Pages 1028-1035Publisher
KOREAN INSTITUTE CHEMICAL ENGINEERS
DOI: 10.1007/s11814-013-0287-1
Keywords
Molecularly Imprinted Polymers; Risperidone; Sustained Release; Human Plasma; Miniemulsion Polymerization
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We prepared high selective imprinted nanoparticle polymers by a miniemulsion polymerization technique, using risperidone as the template, MAA as the functional monomers, and TRIM as the cross-linker in acetonitrile as solvent. The morphology of the nanoparticles determined by scanning electron microscopy (SEM) images and drug release, binding properties and dynamic light scattering (DLS) of molecularly imprinted polymers (MIPs) were studied. Controlled release of risperidone from nanoparticles was investigated through in 1% wt sodium dodecyl sulfate aqueous solution and by measuring the absorbance by HPLC-UV. The results showed that the imprinted nanoparticles exhibited a higher binding level and slower release rate than non-imprinted nanoparticles, which contributed to interaction of risperidone with imprinted cavities within nanoparticles. Furthermore, the results from HPLC showed good precision (5% for 50.0 mu g L-1) and recoveries (between 86-91) using MIP from human plasma samples.
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