Journal
KOREAN JOURNAL OF CHEMICAL ENGINEERING
Volume 28, Issue 6, Pages 1347-1350Publisher
KOREAN INSTITUTE CHEMICAL ENGINEERS
DOI: 10.1007/s11814-010-0509-8
Keywords
Hydrogel Microparticles; Cosmetic Ingredients; Arbutin; Adenosine; Niacinamide; pH-sensitive; Smart Delivery System; Skin Permeability
Funding
- Hongik University
- Ministry of Knowledge Economy, Republic of Korea [10029539]
- Korea Institute of Industrial Technology(KITECH) [10029539] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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pH-Sensitive P(MAA-co-EGMA) hydrogel microparticles were prepared and their feasibility as smart delivery carriers for cosmetically active ingredients such as arbutin, adenosine, and niacinamide was evaluated. P(MAAco-EGMA) hydrogel microparticles were synthesized via dispersion photopolymerization. There was a drastic change in the swelling ratio of P(MAA-co-EGMA) microparticles at a pH of around 5. The loading efficiency of the cosmetic ingredients was affected by the electrostatic interaction between the hydrogel and the cosmetic ingredients. The P(MAAco-EGMA) hydrogel microparticles showed a pH-sensitive release behavior. Thus, at pH 4 almost none of the cosmetic ingredients except adenosine permeated through the skin, while at pH 6 relatively high skin permeability was obtained. These results indicate that the P(MAA-co-EGMA) hydrogel microparticles synthesized in this study have the potential to be used as a smart carrier for cosmetic ingredients triggered by an external pH change for cosmetic applications.
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