Journal
PSYCHIATRY RESEARCH-NEUROIMAGING
Volume 233, Issue 3, Pages 331-338Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2015.05.017
Keywords
Body-mass index; IMRI; Functional connectivity; Graph analysis; Brain
Categories
Funding
- Max Planck International Research Network on Aging (MaxNetAging)
- Catalan Government [FI-DGR 2012, BE-DGR 2012]
- Spanish Ministry of Economy and Competitiveness [PSI2013-48045-C2]
- German Federal Ministry of Education and Research, Germany [FKZ: 01EO1001]
- German Research Foundation [SFB 1052]
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Obesity is associated with structural and functional alterations in brain areas that are often functionally distinct and anatomically distant. This suggests that obesity is associated with differences in functional connectivity of regions distributed across the brain. However, studies addressing whole brain functional connectivity in obesity remain scarce. Here, we compared voxel-wise degree centrality and eigenvector centrality between participants with obesity (n = 20) and normal-weight controls (n = 21). We analyzed resting state and task-related fMRI data acquired from the same individuals. Relative to normal-weight controls, participants with obesity exhibited reduced degree centrality in the right middle frontal gyrus in the resting-state condition. During the task fMRI condition, obese participants exhibited less degree centrality in the left middle frontal gyros and the lateral occipital cortex along with reduced eigenvector centrality in the lateral occipital cortex and occipital pole. Our results highlight the central role of the middle frontal gyrus in the pathophysiology of obesity, a structure involved in several brain circuits signaling attention, executive functions and motor functions. Additionally, our analysis suggests the existence of task-dependent reduced centrality in occipital areas; regions with a role in perceptual processes and that are profoundly modulated by attention. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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