Journal
PSYCHIATRY RESEARCH
Volume 229, Issue 1-2, Pages 57-62Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2015.07.072
Keywords
Bipolar disorders; Brain-derived neurotrophic factor; Exercise; Neurogenesis
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Funding
- Grupo de Pesquisa e Pos-Graduacao (GPPG) of the Hospital de Clinicas de Porto Alegre
- Coordenacao de aperfeicoamento de pessoal de nivel superior (CAPES)
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Acute exercise increases brain-derived neurotrophic factor (BDNF) serum levels in majorly depressed and anxious patients. However, to the best of our knowledge, no study has evaluated the acute effects of exercise on BDNF serum levels in Bipolar Disorder (BD). The objective of the present study was to evaluate the peripheral BDNF serum response to a single maximum session of exercise in BD participants and age- and gender-matched healthy participants. BD participants (n=18) and age- and gender-matched healthy participants (n=18) were recruited to perform a single bout of maximal exercise on a cycle ergometer. Blood samples were collected prior to and immediately after the exercise protocol. There was a significant group effect and a significant group x time x gender interaction. BD participants presented significantly higher BDNF serum levels when compared to their healthy control counterparts. Exercise increases the BDNF levels of BD women, but not men. (C) 2015 Published by Elsevier Ireland Ltd.
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