Journal
PSYCHIATRY RESEARCH
Volume 229, Issue 3, Pages 1031-1037Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2015.05.021
Keywords
Autism spectrum disorder; Core symptoms; Metabolism; Homocysteine; Language development; Biomarker
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Funding
- University of Valencia [UV-INV_PRECOMP13-115500]
- Conselleria de Educacion (Generalitat Valenciana) [GV2014-043]
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The clinical significance of high levels of homocysteine in autism spectrum disorder (ASD) is unknown. An experimental study was conducted in order to evaluate the concentration of homocysteine in children with ASD and typically developing children and to analyse any relationships with the severity of core symptoms of ASD and other clinical features (drugs, co-morbidities, gender, age, diet). Core symptoms of autism were evaluated by DSM-IV criteria. Homocysteine, glutathione, methionine, 3-nitrotyrosine were measured in urine. The increase in homocysteine concentration was significantly and directly correlated with the severity of the deficit in communication skills, but was unrelated to deficit in socialisation or repetitive/restricted behaviour. Urinary homocysteine concentration may be a possible biomarker for communication deficits in ASD and a potential diagnostic tool useful to evaluate new treatment options since no treatment for core symptoms of ASD are available. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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