Journal
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
Volume 227, Issue 9, Pages 701-711Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0029-1245718
Keywords
retina; diabetic macular oedema; anti-VEGF therapy
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Diabetic macular edema (DME) and proliferative retinopathy are common causes for blindness in middle-aged patients. The gold standard for treatment has been laser coagulation. Limitations of this therapy are refractive DME, ischaemic diabetic maculopathy and complications after laser application. The need for a non-destructive and effective strategy has led to investigations regarding vascular endothelial growth factor (VEGF) inhibitors for reduction of vessel leakage and oedema formation. VEGF antibody fragments have been approved for age-associated macular degeneration (AMD) in different countries and have proved to be safe and effective. Trials for different anti-VEGF compounds are nearing completion or are completed. Published data show a superiority of anti-VEGF therapy compared to laser coagulation. In the present article, data regarding dose, injection scheme and practicable application form are reviewed.
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