Journal
PSYCHIATRY RESEARCH
Volume 229, Issue 3, Pages 844-849Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2015.07.078
Keywords
Aggression; Inflammation; Fluoxetine; Divalproex
Categories
Funding
- NIMH [RO1MH66884, R01-AG034588, R01 AG026364, CA160245, R01DA032922, R01 HL095799-01, P30 AG028748, R01-CA119159, UL RR 033176]
- Cousins Center for Psychoneuroimmunology
- UCLA Claude D. Pepper Older Americans Independence Center
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Intermittent Explosive Disorder (IED) is a disorder of impulsive aggression affecting 4-7% of the U.S. population during some period of life. In addition to other biological correlates, elevations of plasma inflammatory markers have been reported in IED, compared with control, subjects. In this study we sought to explore if treatment exposure to anti-aggressive agents, compared with placebo, would be associated with a reduction in circulating levels of inflammatory markers. Thirty IED subjects, from a 12-week, double-blind, randomized, placebo-controlled trial of fluoxetine and divalproex, in which both pre- and post-treatment levels of C-Reactive Protein (CRP), interleukin (IL)-1 beta, IL-2, IL-6, IL-8, IL-10 and tumor necrosis factor (TNF)-alpha were obtained. Efficacy measures included the Overt Aggression Scale-Modified (OAS-M) score for Aggression and for Irritability, rate of Clinical Global Impression of Improvement (CGI-I), and rate of IED Remitters at study completion. As compared to placebo, neither fluoxetine nor divalproex reduced any of the measures of aggression. In addition, levels of CRP and pro- and anti-inflammatory cytokines showed no changes from pre- to post-treatment for any treatment condition. Correlations between pre- and post- treatment plasma CRP/cytokines were substantial (mean r=0.71, r(2)=0.50, p < 0.001). Overall, circulating markers of inflammation markers were unaffected by treatment with fluoxetine or divalproex, consistent with the absence of change in measures of impulsive aggression. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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