Journal
KIDNEY INTERNATIONAL
Volume 85, Issue 3, Pages 590-599Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ki.2013.457
Keywords
B cell; chronic antibody-mediated rejection; kidney transplantation; regulatory B cells
Categories
Funding
- Ministere de l'Education Nationale, de la Recherche et de la Technologie
- Agence Nationale de la Recherche under the 'Investissements d'avenir' program [ANR-11-LABX-0016-013]
- Agence de la Biomedecine (AOR 'Recherche et Greffe 2013')
Ask authors/readers for more resources
In kidney transplantation, the composition of the B-cell compartment is increasingly identified as an important determinant for graft outcome. Whereas naive and transitional B cells have been associated with long-term allograft survival and operational tolerance, memory B cells have been linked to graft rejection and graft loss. Chronic antibody-mediated rejection now represents a major complication in transplantation and is a challenge in current therapeutics. Here, we show that patients with chronic antibody-mediated rejection display a unique B-cell phenotype with a reduced ratio of activated to memory B cells associated with an impaired immunosuppressive activity. The regulatory functions of the B cells depended on their maturation status. Thus, phenotypic and functional analyses of the B-cell compartment may be indicated for appropriate follow-up after transplantation and drive therapy in the establishment of transplant tolerance processes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available