Journal
KIDNEY INTERNATIONAL
Volume 83, Issue 4, Pages 541-543Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/ki.2012.434
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Funding
- NIDDK NIH HHS [R01 DK079996, R01 DK 079996, R01 DK033665] Funding Source: Medline
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Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22(phox) mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeutic intervention utilizing small-molecule inhibitors specifically targeting Nox oxidases to prevent or slow down the progression of chronic kidney disease and the associated disorders due to uremic toxicity. Kidney International (2013) 83, 541-543. doi:10.1038/ki.2012.434
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