Journal
KIDNEY INTERNATIONAL
Volume 81, Issue 4, Pages 338-340Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/ki.2011.401
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- NIDDK NIH HHS [R01 DK034275] Funding Source: Medline
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Oxidant stress and compromised microcirculation underlie renal pathophysiology in septic acute kidney injury (AKI). Holthoff et al. report that resveratrol ameliorates these coupled abnormalities. They did not establish the primacy of either defect in septic AKI. However, tubule mitochondrial defects were recently reported to be involved in septic AKI pathogenesis, and resveratrol targets PGC-1 alpha and respiratory enzymes. Together, these findings open new avenues for research into long-unresolved issues in the pathophysiology of septic AKI. Kidney International (2012) 81, 338-340. doi:10.1038/ki.2011.401
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