Journal
KIDNEY INTERNATIONAL
Volume 81, Issue 9, Pages 809-811Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ki.2012.11
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Funding
- NIDDK NIH HHS [R01 DK039773-26, R01 DK072381, R01 DK072381-08, F32 DK088418, R01 DK039773] Funding Source: Medline
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Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory molecule for immune cells, its potential immunological role has been controversial. In the presence of very high epithelial cell expression, understanding the influence of immune cell Kim-1/Tim-1 expression in kidney injury relies on a better definition of its functional significance in immune cells and better characterization of antibodies used to probe function. Kidney International (2012) 81, 809-811. doi:10.1038/ki.2012.11
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