Journal
KIDNEY INTERNATIONAL
Volume 81, Issue 11, Pages 1131-1139Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/ki.2012.6
Keywords
albuminuria; cardiovascular disease; diabetic nephropathy
Categories
Funding
- Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health [1994DP131044]
- Ministry of Health [201002002]
- Ministry of Science and Technology [2008ZX09312/019, 2008BAI52B03]
- Creative Research Group of Ministry of Education [IRT0932]
- National Natural Science Foundation [30725037, 81170719, 30900700]
- Shanghai Committee of Science and Technology [09DZ1950200]
- Technology Commission of Shanghai Municipality [10140902900, 10PJ1408900]
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Bisphenol A is an industrial chemical widely used in plastic products with a consequent exposure to humans. To assess whether exposure to bisphenol A is associated with renal disease, we searched for low-grade albuminuria in 3055 Chinese adults in the Shanghai metropolitan area aged 40 years or older. Using a value for urinary albumin-to-creatinine ratios <30 mg/g, we examined its association with urinary bisphenol A. Participants in the highest compared to the lowest quartile of urinary bisphenol A concentrations were significantly more likely to have low-grade albuminuria. Multivariate stepwise linear regression analysis, adjusted for potential confounding factors, showed that urinary bisphenol A was an independent determinant of the urinary albumin-to-creatinine ratio significantly associated with an increased risk of low-grade albuminuria with an adjusted odds ratio of 1.23 for the highest compared to the lowest concentration quartiles. This association was not modified by conventional risk factors such as age, gender, smoking, alcohol consumption, body mass index, hypertension, diabetes, and the estimated glomerular filtration rate. There was no significant relationship between bisphenol A and combined micro- and macroalbuminuria. Thus, our study lends support to a potential relation between bisphenol A exposure and an increased risk of low-grade albuminuria. Kidney International (2012) 81, 1131-1139; doi: 10.1038/ki.2012.6; published online 7 March 2012
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