Journal
KIDNEY INTERNATIONAL
Volume 77, Issue 6, Pages 550-556Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/ki.2009.503
Keywords
cardiovascular disease; chronic kidney disease; inflammation; mortality; vascular calcification
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Funding
- Amiens University Hospital [PHRC: 2006/0100 (27/03/2006)]
- EUTox Group
- Picardy Regional Council/University of Picardy Jules Verne
- National Council of Technological and Scientific Development, Brazil
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Chronic inflammation associated with chronic kidney disease predicts all-cause and cardiovascular mortality in hemodialysis patients. Here we sought to evaluate the association between plasma levels of the inflammatory mediator interleukin-6 (IL-6) and mortality and aortic calcification/stiffness in 125 patients at different stages (2-5D) of chronic kidney disease. Using multivariate linear regression, we found that plasma IL-6 was independently associated with C-reactive protein, albumin and the stage of chronic kidney disease, but not the aortic calcification score or pulse wave velocity. During follow-up studies (median of 829 days), 38 patients died, 22 from cardiovascular events. Plasma IL-6 significantly predicted overall and cardiovascular mortality; this association persisted after multiple adjustments or restricting the analysis to pre-dialysis patients. Moreover, IL-6 was a significantly better predictor of mortality than C-reactive protein, albumin or tumor necrosis factor-a. Hence, plasma IL-6 independently predicted overall and cardiovascular mortality in patients at different stages of chronic kidney disease; however, whether lowering plasma IL-6 will affect the outcome of chronic kidney disease will require more direct evaluation. Kidney International (2010) 77, 550-556; doi: 10.1038/ki.2009.503; published online 16 December 2009
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