Journal
KIDNEY INTERNATIONAL
Volume 75, Issue 2, Pages 176-184Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ki.2008.456
Keywords
vascular calcification; renal osteodystrophy; chronic kidney disease; hyperphosphatemia; hyperparathyroidism
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Funding
- Genzyme Inc
- NIH [DK063934]
- Indiana Genomics Initiative (INGEN) of Indiana University
- Lilly Endowment Inc
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK063934] Funding Source: NIH RePORTER
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Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is a newly defined syndrome encompassing patients with chronic kidney disease that have a triad of biochemical alterations in calcium, phosphorus and parathyroid hormone, vascular calcification, and bone abnormalities. Here we describe a novel Cy/+ rat model of slowly progressive kidney disease spontaneously developing the three components of CKD-MBD when fed a normal phosphorus diet. Since the renal disorder progressed 'naturally' we studied the effect of dietary manipulation during the course of the disease. Animals with early, but established, chronic kidney disease were fed a casein-based or a grain-based protein diet both of which had equivalent total phosphorus contents. The two different sources of dietary protein had profound effects on the progression of CKD-MBD, likely due to differences in intestinal bioavailability of phosphorus. Although both dietary treatments resulted in the same serum phosphorous levels, the casein-fed animals had increased urinary phosphorus excretion and elevated serum FGF23 compared to the grain-fed rats. This model should help identify early changes in the course of chronic kidney disease that may lead to CKD-MBD.
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