Journal
KIDNEY INTERNATIONAL
Volume 74, Issue 1, Pages 22-36Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/ki.2008.128
Keywords
podocyte; mesangial cell; glomerular endothelial cell; diabetic nephropathy; albuminuria; proteinuria
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Funding
- NIDDK NIH HHS [DK60525, DK51096, DK56799] Funding Source: Medline
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Proteinuria is the hallmark of diabetic kidney disease (DKD) and is an independent risk factor for both renal disease progression, and cardiovascular disease. Although the characteristic pathological changes in DKD include thickening of the glomerular basement membrane and mesangial expansion, these changes per se do not readily explain how patients develop proteinuria. Recent advances in podocyte and glomerular endothelial cell biology have shifted our focus to also include these cells of the glomerular filtration barrier in the development of proteinuria in DKD. This review describes the pathophysiological mechanisms at a cellular level which explain why patients with DKD develop proteinuria.
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