4.7 Editorial Material

Macrophages and hypoxia in human chronic kidney disease

Journal

KIDNEY INTERNATIONAL
Volume 74, Issue 4, Pages 405-406

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/ki.2008.225

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Chronic kidney disease is characterized by progressive interstitial fibrosis, reduced blood flow, and tubular atrophy, which present a common pathway of destruction irrespective of the initial underlying pathology. There is comprehensive evidence that the interactions of infiltrating macrophages with resident tissue cells play a critical role in this process. A new study now describes the correlation between macrophages, capillary density, and interstitial scarring and suggests distinct differences in early and advanced renal disease.

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