Journal
KIDNEY INTERNATIONAL
Volume 74, Issue 3, Pages 259-261Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/ki.2008.260
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Funding
- NIDDK NIH HHS [R21 DK074613, P30 DK079333] Funding Source: Medline
- NIGMS NIH HHS [R01 GM060432] Funding Source: Medline
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The concept that the glomerular filtration barrier exhibits charge selectivity is a basic tenet of renal physiology. Heparan sulfate is a major contributor of glomerular anionic charge. In a new study, prevention of podocytes from synthesizing heparan sulfate, via mutation of Ext1, causes only mild, statistically insignificant albuminuria, despite dramatic alterations in glomerular anionic charge.
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