Journal
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
Volume 29, Issue 11, Pages 606-610Publisher
ELSEVIER TAIWAN
DOI: 10.1016/j.kjms.2013.04.002
Keywords
EBER1; Inflammation; Rheumatoid arthritis
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Funding
- National Science Council, Taiwan, ROC [99-2314-B-182-011]
- Chang Gung Medical Foundation
- Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan [BMRP743]
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Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by perpetuated inflammation in multiple joints. To date, there is no cure for RA, and the causal factor for non-resolving inflammation in RA remains unclear. In this study, we initially observed expression of Epsteine-Barr virus-encoded small RNA1 (EBER1) in the synovial tissue of all five patients who showed nonresolving RA inflammation. By contrast, EBER1 was detected in the synovial tissue of only one out of seven patients with advanced osteoarthritis (OA; p < 0.01, Fisher's exact test). To confirm this finding, we conducted a second study on synovial tissue samples taken from 23 patients with nonresolving RA inflammation and 13 patients with OA. All synovial samples from patients with nonresolving inflammation of RA showed positive expression of EBER1 (23/23, 100%), whereas none of the synovial samples from patients with OA showed expression of EBER1 (0/13, 0%; p < 0.001, by Fisher's exact test). In vitro, transfection of RA synovial fibroblasts with EBER1 induced the production of interleukin-6. Taken together, these data strongly suggest that nonresolving RA inflammation is strongly related to the presence of EBER1, which might be, at least partially, responsible for synovial fibroblast interleukin-6 production. Copyright (C) 2013, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.
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