Journal
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
Volume 28, Issue 2, Pages 63-71Publisher
WILEY
DOI: 10.1016/j.kjms.2011.06.028
Keywords
Endometrial cancer; Endometriurn; Side-population cells (SP cells); Stem cells
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan [20659259, 22659302, 22591869]
- Ministry of the Environment, Japan
- Grants-in-Aid for Scientific Research [22659302, 22591869, 20659259] Funding Source: KAKEN
Ask authors/readers for more resources
Recently, adult stem cells have been identified in several mature tissues. The human endometrium is responsive to sex steroid hormone. It undergoes extraordinary growth in a cyclic manner and is shed and regenerated throughout a woman's lifetime. It has been proposed that the human endometrium may contain a population of stem cells, which are responsible for its remarkable regenerative ability. It is also suggested that stem-like cells exist in cancer tissues. Stem-like cell subpopulations, referred to as side population (SP) cells, have been identified in several tissues and tumors based on their ability to efflux the fluorescent dye Hoechst 33342. Recently, we isolated and characterized the SP cells in normal human endometrium and in an endometrial cancer (EC) cell line. Endometrial SP cells can function as progenitor cells. EC SP cells show the following: (1) reductions in the expression levels of differentiation markers; (2) long-term repopulating properties; (3) self-renewal capacity; (4) enhancement of migration and podia formation; (5) enhancement of tumorigenicity; and (6) bipotent developmental potential (tumor cells and stroma-like cells), suggesting that these SP cells have cancer stem-like cell features. We review the articles that show the presence of stem cells in normal endometrium and EC cells and demonstrate the results of our studies. Copyright (C) 2011, Elsevier Taiwan LLC. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available