Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 69, Issue 6, Pages 695-701Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glt196
Keywords
Frailty; Nutrition; Epidemiology
Categories
Funding
- National Institutes of Health: the National Institute of Arthritis and Musculoskeletal and Skin Diseases [U01 AR45580, U01 AR45614, U01 AR45632, U01 AR45647, U01 AR45654, U01 AR45583]
- National Institute on Aging [U01 AG18197, U01 AG027810]
- National Center for Research Resources [UL1 RR024140]
- National Institutes of Health Roadmap for Medical Research
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Background. Frailty, a phenotype of multisystem impairment and expanding vulnerability, is associated with higher risk of adverse health outcomes not entirely explained by advancing age. We investigated associations of macronutrients, dietary fiber, and overall diet quality with frailty status in older community-dwelling men. Methods. Participants were 5,925 men aged >= 65 years enrolled in the Osteoporotic Fractures in Men (MrOS) study at six U. S. centers. Diet was assessed at baseline with a food frequency questionnaire. We assessed frailty status (robust, intermediate, or frail) at baseline and at a second clinic visit (a mean of 4.6 years later) using a slightly modified Cardiovascular Health Study frailty index. We used multinomial logistic regression to assess associations between macronutrient intake, dietary fiber, and the Diet Quality Index Revised with frailty status at baseline and at the second clinic visit. Results. At baseline, 2,748 (46.4%) participants were robust, 2,681 (45.2%) were intermediate, and 496 (8.4%) were frail. Carbohydrate, fat, protein, and dietary fiber showed no consistent associations with frailty status. Overall diet quality exhibited fairly consistent associations with frailty status. The Diet Quality Index Revised was inversely associated with frail status relative to robust status at the baseline visit (odds ratio for Q5 vs Q1 = 0.44, 95% confidence interval: 0.30, 0.63; p for trend < .0001) and at the second clinic visit (odds ratio for Q5 vs Q1 = 0.18, 95% confidence interval: 0.03, 0.97; p for trend = .0180). Conclusions. Overall diet quality was inversely associated with prevalent and future frailty status in this cohort of older men.
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