Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 67, Issue 6, Pages 599-610Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/gls072
Keywords
Vascular aging; Myocardial infarction; Vascular dementia; Atherosclerosis; Endothelial dysfunction
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Funding
- Donald W. Reynolds Foundation
- American Federation for Aging Research
- Oklahoma Center for the Advancement of Science and Technology
- American Heart Association
- National Institutes of Health [AG031085, AT006526]
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This review focuses on cardiovascular protective effects of insulin-like growth factor (IGF)-1, provides a landscape of molecular mechanisms involved in cardiovascular alterations in patients and animal models with congenital and adult-onset IGF-1 deficiency, and explores the link between age-related IGF-1 deficiency and the molecular, cellular, and functional changes that occur in the cardiovascular system during aging. Microvascular protection conferred by endocrine and paracrine IGF-1 signaling, its implications for the pathophysiology of cardiac failure and vascular cognitive impairment, and the role of impaired cellular stress resistance in cardiovascular aging considered here are based on emerging knowledge of the effects of IGF-1 on Nrf2-driven antioxidant response.
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