Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 67, Issue 8, Pages 841-852Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glr216
Keywords
Primates; Comparative biology; Free radical; Oxidative stress
Categories
Funding
- American Diabetes Association
- American Federation for Aging Research
- American Heart Association
- Oklahoma Center for the Advancement of Science and Technology
- University of Oklahoma College of Medicine Alumni Association
- San Antonio Area Foundation
- National Institutes of Health [AG031085, AT006526, AG022873, AG025063]
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The present study was conducted to test predictions of the oxidative stress theory of aging assessing reactive oxygen species production and oxidative stress resistance in cultured fibroblasts from 13 primate species ranging in body size from 0.25 to 120 kg and in longevity from 20 to 90 years. We assessed both basal and stress-induced reactive oxygen species production in fibroblasts from five great apes (human, chimpanzee, bonobo, gorilla, and orangutan), four Old World monkeys (baboon, rhesus and crested black macaques, and patas monkey), three New World monkeys (common marmoset, red-bellied tamarin, and woolly monkey), and one lemur (ring-tailed lemur). Measurements of cellular MitoSox fluorescence, an indicator of mitochondrial superoxide (O-2(center dot-)) generation, showed an inverse correlation between longevity and steady state or metabolic stress induced mitochondrial O-2(center dot-) production, but this correlation was lost when the effects of body mass were removed, and the data were analyzed using phylogenetically independent contrasts. Fibroblasts from longer-lived primate species also exhibited superior resistance to H2O2-induced apoptotic cell death than cells from shorter-living primates. After correction for body mass and lack of phylogenetic independence, this correlation, although still discernible, fell short of significance by regression analysis. Thus, increased longevity in this sample of primates is not causally associated with low cellular reactive oxygen species generation, but further studies are warranted to test the association between increased cellular resistance to oxidative stressor and primate longevity.
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