Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 67, Issue 10, Pages 1099-1106Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/gls077
Keywords
Aging; Adiposity; Inflammation; Muscle impairment; Factor analysis
Categories
Funding
- National Institutes of Health [U01-AG22376]
- National Institute on Aging (NIA [R01-AG027529]
- NIA Intramural Research Program
- Wake Forest Claude D. Pepper Older Americans Independence Center [P30-AG21332]
- University of Florida Claude D. Pepper Older Americans Independence Center [P30-AG028740]
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Obesity-related increases in multiple inflammatory markers may contribute to the persistent subclinical inflammation common with advancing age. However, it is unclear if a specific combination of markers reflects the underlying inflammatory state. We used factor analysis to identify inflammatory factor(s) and examine their associations with adiposity in older adults at risk for disability. Adiponectin, CRP, IL-1ra, IL-1sRII, IL-2sR alpha, IL-6, IL-6sR, IL-8, IL-15, sTNFRI, sTNFRII, and TNF-alpha were measured in 179 participants from the Lifestyle Interventions and Independence for Elders Pilot (Mean +/- SD age 77 +/- 4 years, 76% white, 70% women). Body mass index, waist circumference, and total fat mass were assessed by anthropometry and dual-energy x-ray absorptiometry. IL-2sR alpha, sTNFRI, and sTNFRII loaded highest on the first factor (factor 1). CRP, IL-1ra, and IL-6 loaded highest on the second factor (factor 2). Factor 2, but not factor 1, was positively associated with 1-SD increments in waist circumference (beta = 0.160 +/- 0.057, p = .005), body mass index (beta = 0.132 +/- 0.053, p = .01), and total fat mass (beta = 0.126 +/- 0.053, p = .02) after adjusting for age, gender, race/ethnicity, site, smoking, anti-inflammatory medications, comorbidity index, health-related quality of life, and physical function. These associations remained significant after further adjustment for grip strength, but only waist circumference remained associated with inflammation after adjusting for total lean mass. There were no significant interactions between adiposity and muscle mass or strength for either factor. Greater total and abdominal adiposity are associated with higher levels of an inflammatory factor related to CRP, IL-1ra, and IL-6 in older adults, which may provide a clinically useful measure of inflammation in this population.
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