Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 67, Issue 6, Pages 587-598Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/gls115
Keywords
IGF-1; Longevity; Growth hormone
Categories
Funding
- National Institutes of Health [NS056218, AG11370, AG27147, AG031085, AT006526]
- American Federation for Aging Research
- Oklahoma Center for the Advancement of Science and Technology
- American Heart Association
- Ellison Medical Foundation
- Donald W. Reynolds Foundation
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Because the initial reports demonstrating that circulating growth hormone and insulin-like growth factor-1 decrease with age in laboratory animals and humans, there have been numerous studies related to the importance of these hormones for healthy aging. Nevertheless, the role of these potent anabolic hormones in the genesis of the aging phenotype remains controversial. In this chapter, we review the studies demonstrating the beneficial and deleterious effects of growth hormone and insulin-like growth factor-1 deficiency and explore their effects on specific tissues and pathology as well as their potentially unique effects early during development. Based on this review, we conclude that the perceived contradictory roles of growth hormone and insulin-like growth factor-1 in the genesis of the aging phenotype should not be interpreted as a controversy on whether growth hormone or insulin-like growth factor-1 increases or decreases life span but rather as an opportunity to explore the complex roles of these hormones during specific stages of the life span.
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