Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 67, Issue 1, Pages 3-+Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glr167
Keywords
CoQ(10); Mediterranean diet; Chronic inflammation; Endoplasmic reticulum stress; Gene expression
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Funding
- Ministerio de Ciencia e Innovacion [AGL 2004-07907, AGL2006-01979, AGL2009-12270, FIS PI10/01041]
- Consejeria de Innovacion, Ciencia y Empresa, Junta de Andalucia [P06-CTS-01425, CTS5015]
- Consejeria de Salud, Junta de Andalucia [06/128, 07/43, PI0193/2009, 06/129, PI-0252/09, PI-0058/10]
- Kaneka Corporation (Japan)
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We have investigated whether the quality of dietary fat and supplementation with coenzyme Q(10) (CoQ) modifies expression of genes related with inflammatory response and endoplasmic reticulum stress in elderly persons. Twenty participants received three diets for 4 weeks each: Mediterranean diet + CoQ (Med + CoQ), Mediterranean diet (Med), and saturated fatty acid-rich diet (SFA). After 12-hour fast, volunteers consumed a breakfast with a fat composition similar to that consumed in each of the diets. Med and Med + CoQ diets produced a lower fasting calreticulin, IL-1b, and JNK-1 gene expression; a lower postprandial p65, IKK-b, MMP-9, IL-1b, JNK-1, sXBP-1, and BiP/Grp78 gene expression; and a higher postprandial IkB-a gene expression compared with the SFA diet. Med + CoQ diet produced a lower postprandial decrease p65 and IKK-b gene expression compared with the other diets. Our results support the anti-inflammatory effect of Med diet and that exogenous CoQ supplementation in synergy with a Med diet modulates the inflammatory response and endoplasmic reticulum stress.
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