Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 67, Issue 8, Pages 830-840Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glr212
Keywords
Growth hormone receptor; Plasma; Proteomics; Sex; Aging
Categories
Funding
- National Institute of Aging [AG19899, AG031736]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK075436]
- State of Ohio's Eminent Scholar Program
- DiAthegen LLC
- Diabetes Research Initiative at Ohio University
- AMVETS
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Growth hormone receptor gene disrupted (GHR-/-) mice are dwarf, insulin sensitive, and long lived despite being obese. In order to identify characteristics associated with their increased longevity, we studied age-related plasma proteomic changes in these mice. Male and female GHR-/- mice and their littermate controls were followed longitudinally at 8, 16, and 24 months of ages for plasma proteomic analysis. Relative to control littermates, GHR-/- mice had increased levels of apolipoprotein A-4 and retinol-binding protein-4 and decreased levels of apolipoprotein E, haptoglobin, and mannose-binding protein-C. Female GHR-/- mice showed decreased inflammatory cytokines including interleukin-1 beta and monocyte chemotactic protein-1. Additionally, sex differences were found in specific isoforms of apolipoprotein E, RBP-4, haptoglobin, albumin, and hemoglobin subunit beta. In conclusion, we find plasma proteomic changes in GHR-/- mice that favor a longer life span as well as sex differences indicative of an improved health span in female mice.
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