Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 65, Issue 10, Pages 1028-1041Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glq113
Keywords
Vascular aging; Oxidative stress; Endothelial dysfunction; Atherosclerosis; Stroke; Myocardial infarction
Categories
Funding
- American Diabetes Association
- American Federation for Aging Research
- National Institutes of Health (NIH) [HL077256, HL43023, AG11370]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL043023, R01HL077256] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [ZIAAG000362, P01AG011370, ZIAAG000361, ZIAAG000363, ZIAAG000368] Funding Source: NIH RePORTER
Ask authors/readers for more resources
This review focuses on molecular, cellular, and functional changes that occur in the vasculature during aging; explores the links between mitochondrial oxidative stress, inflammation, and development of vascular disease in the elderly patients; and provides a landscape of molecular mechanisms involved in cellular oxidative stress resistance, which could be targeted for the prevention or amelioration of unsuccessful vascular aging. Practical interventions for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the effects of anti-inflammatory treatments, regular exercise, dietary interventions, and caloric restriction mimetics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available