Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 65, Issue 3, Pages 236-241Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glp211
Keywords
Procyanidins; Aging; Oxidative stress; Lipid peroxidation; Antioxidant enzymes
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Funding
- National Key Technology R&D Program of China [2006BAD27B08, 2006BAD27B09-4]
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The alleviative effect of procyanidins extracted from the lotus seedpod (LSPC) on oxidative stress in various tissues was evaluated by determining the activities of the antioxidant enzymes and the content of reduced glutathione (GSH) in heart, liver, lung, kidney. skeletal muscle, and serum in aged rats. Aging led to antioxidant deficit in various tissues in this study, which is confirmed by remarkable increased lipid peroxidation, whereas the change patterns of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and GSH were diverse in various tissues of aged rats. LSPC treatment (50 and 100 mg/kg body weight) modified the activity of SOD, CAT. and GPx as well as GSH content alteration in these tissues, which reversed the age-related antioxidant deficit in aged rats. However, the regulatory patterns on the activities of these enzymes and GSH content by LSPC treatment were different according to the tissues in aged rats.
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