Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 65, Issue 11, Pages 1185-1192Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glq128
Keywords
Aging; Testosterone; Cortisol
Categories
Funding
- National Center for Complementary and Alternative Medicine, Bethesda, Maryland
- National Institute on Aging, Baltimore, Maryland
- National Institutes of Health [RO-1 AG11005, DK073148]
- National Center for Research Resources, National Institutes of Health, Bethesda, Maryland [MO-1-RR-02719]
- Department of Veterans Affairs and Veterans Affairs Medical Center Baltimore Geriatrics Research, Education and Clinical Center
- Claude D. Pepper Older Americans Independence Center at the University of Maryland [P60-AG-12583]
- Research Service, Veterans Affairs Medical Center, Washington DC
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In animal studies, testosterone decreases, whereas estrogen increases, cortisol production. In one clinical study, short-term testosterone replacement attenuated corticotrophin-releasing hormone-stimulated cortisol secretion during leuprolide-induced hypogonadism in young men. The effects of longer term testosterone treatment on spontaneous cortisol secretion in younger or older men are unknown. In a randomized, double-masked placebo-controlled study, we assessed the effects of testosterone supplementation (100 mg intramuscular every 2 week) for 26 weeks on nocturnal cortisol secretory dynamics in healthy older men. Testosterone administration increased early morning serum concentrations of free testosterone by 34%, decreased sex hormone-binding globulin by 20%, and did not alter early morning concentrations of cortisol-binding globulin or cortisol compared with placebo treatment. Testosterone did not significantly alter nocturnal mean and integrated cortisol concentrations, cortisol burst frequency, mass/burst, basal secretion, pulsatile cortisol production rate, pattern regularity, or approximate entropy. We conclude that low-dose testosterone supplementation for 26 weeks does not affect spontaneous nocturnal cortisol secretion in healthy older men.
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