Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 65, Issue 1, Pages 31-40Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glp175
Keywords
Body composition; Growth hormone; Obesity; Adipose depots; Gender differences
Categories
Funding
- NIDDK [DK064905]
- National Institute on Aging [AG031736, AG19899]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK075436]
- State of Ohio's Eminent Scholar Program
- Milton and Lawrence Goll
- DiAthegen
- American Veterans (AMVETS)
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R15DK075436, K01DK064905] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG019899, P01AG031736] Funding Source: NIH RePORTER
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Growth hormone receptor gene-disrupted (GHR-/-) mice exhibit increased life span and adipose tissue mass. Although this obese phenotype has been reported extensively for young adult male GHR-/- mice, data for females and for other ages in either gender are lacking. Thus, the purpose of this study was to evaluate body composition longitudinally in both male and female GHR-/- mice. Results show that GHR-/- mice have a greater percent fat mass with no significant difference in absolute fat mass throughout life. Lean mass shows an opposite trend with percent lean mass not significantly different between genotypes but absolute mass reduced in GHR-/- mice. Differences in body composition are more pronounced in male than in female mice, and both genders of GHR-/- mice show specific enlargement of the subcutaneous adipose depot. Along with previously published data, these results suggest a consistent and intriguing protective effect of excess fat mass in the subcutaneous region.
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