Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 63, Issue 9, Pages 928-935Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/63.9.928
Keywords
Fiber type; Capillary density; Capillary-to-fiber ratio; Skeletal muscle; Morphometry
Categories
Funding
- National Institutes of Health [PO1 HL-1773]
- TRDRP [14KT-0091]
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Decreased skeletal muscle mass and proportion of fast-twitch glycolytic fibers are well-documented correlates of aging; however, data on concomitant changes on capillary-to-fiber ratio (C:F) are inconsistent. We simultaneously examined fiber-type composition and arteriolar and venular portions of capillaries in the distal hind-limb muscles of 12-, 24-, and 35-month old F1 hybrid F344 Brown Norway rats. Aging significantly increased C:F of venular capillaries in muscles, which also presented significant age-related increase in slow-(type I) and fast-(type IIa) oxidative fibers (plantaris, tibialis anterior, medial gastrocnemius; p < .05). In contrast, arteriolar and venular capillary proportions did not change in the soleus, extensor digitorum longus, or lateral gastrocnemius. These data suggest that age-associated increases in skeletal muscle capillarity may be due to the venular portion of capillaries and that the increase occurs primarily in muscles that demonstrate increased oxidative potential with age.
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