Journal
PROTEOMICS CLINICAL APPLICATIONS
Volume 9, Issue 1-2, Pages 98-110Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/prca.201400094
Keywords
Cancer biomarker; Cancer metastasis; Clinical samples; Protein microarray
Funding
- National High Technology Research and Development Program of China [2012AA020103, 2012AA020203]
- National Natural Science Foundation of China [31370813, 31370750]
- National Science Foundation for Young Scientist [81301502]
- Shanghai Sixth Hospital Funds for Young Scientists [1513]
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Cancer biomarkers are of potential use in early cancer diagnosis, anticancer therapy development, and monitoring the responses to treatments. Protein-based cancer biomarkers are major forms in use, as they are much easier to be monitored in body fluids or tissues. For cancer biomarker discovery, high-throughput techniques such as protein microarrays hold great promises, because they are capable of global unbiased monitoring but with a miniaturized format. In doing so, novel and cancer type specific biomarkers can be systematically discovered at an affordable cost. In this review, we give a relatively complete picture on protein microarrays applied to clinical samples for cancer biomarker discovery, and conclude this review with the future perspectives.
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