Journal
PROTEOMICS
Volume 15, Issue 7, Pages 1235-1238Publisher
WILEY-BLACKWELL
DOI: 10.1002/pmic.201400313
Keywords
Bioinformatics; MS analysis; Proteoform characterization; Proteomics software; Top-down proteomics
Funding
- National Institute on Drug Abuse [P30DA018310]
- National Institute of General Medical Sciences [R01GM067193]
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Many top-down proteomics experiments focus on identifying and localizing PTMs and other potential sources of mass shift on a known protein sequence. A simple application to match ion masses and facilitate the iterative hypothesis testing of PTM presence and location would assist with the data analysis in these experiments. ProSight Lite is a free software tool for matching a single candidate sequence against a set of mass spectrometric observations. Fixed or variable modifications, including both PTMs and a select number of glycosylations, can be applied to the amino acid sequence. The application reports multiple scores and a matching fragment list. Fragmentation maps can be exported for publication in either portable network graphic (PNG) or scalable vector graphic (SVG) format. ProSight Lite can be freely downloaded from , installs and updates from the web, and requires Windows 7 or a higher version.
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