Screening antiacne potency of Indonesian medicinal plants: antibacterial, lipase inhibition, and antioxidant activities

Indonesian medicinal plants were screened as potential sources of antiacne agents. The screening methods were performed using antibacterial assay against Propionibacterium acnes, lipase inhibitor assay, and antioxidant assay. The results showed that from 40 plant materials extracted with methanol and 50% ethanol in water, Caesalpinia sappan was the best extract based on the combined activities: antibacterial (minimum inhibitory concentration 0.13 mg/ml; minimum bactericidal concentration 0.25 mg/ml), lipase inhibitory [50% inhibitory concentration (IC50) 120.0 mu g/ml], and antioxidative (IC50 6.47 mu g/ml). Another prospective extract is Intsia palembanica based on its lipase inhibitory activity (IC50 4.1 mu g/ml) and antioxidant activity (IC50 3.87 mu g/ml).