Journal
PROGRESS IN POLYMER SCIENCE
Volume 44, Issue -, Pages 1-27Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2014.08.002
Keywords
Dendrimers; Molecular imaging; Contrast agents; Organic/inorganic nanohybrids; Radionuclide-based imaging; Cancer diagnosis
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Funding
- National Natural Science Foundation of China [21273032]
- High-Tech Research and Development Program of China [2012AA030309]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of High Learning
- FCT [PTDC/CTM-NAN/1748/2012]
- Fundação para a Ciência e a Tecnologia [PTDC/CTM-NAN/1748/2012] Funding Source: FCT
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This review reports recent advances on the use of dendrimer nanotechnology to build up various contrast agents for different single-mode or dual-mode molecular imaging applications. The versatile dendrimer scaffolds with 3-dimensional spherical shape, highly branched internal cavity, and tunable surface conjugation chemistry enable the facile modification of dendrimer surface with different imaging agents (e.g., fluorescent dyes, traditional small molecular contrast agents, or metal ion/chelator complexes) and targeting ligands, and convenient entrapment, stabilization, and self-assembly to form various organic or organic/inorganic hybrid nanoparticles that can be used as multifunctional contrast agents for both non-radionuclide- and radionuclide-based molecular imaging applications. In particular, strategies used to generate multifunctional nanoprobes for different modes of targeted molecular imaging of cancer are discussed in detail. (C) 2014 Elsevier Ltd. All rights reserved.
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