Journal
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Volume 86-87, Issue -, Pages 1-20Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnmrs.2015.02.002
Keywords
NMR spectroscopy; Pure shift NMR; Scalar coupling; Homonuclear broadband decoupling; Structure analysis
Funding
- Austrian Science Foundation (FWF) [P24742, P27793]
- NAWI Graz
- Austrian Science Fund (FWF) [P24742, P27793] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [P 24742] Funding Source: researchfish
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Although scalar-coupling provides important structural information, the resulting signal splittings significantly reduce the resolution of NMR spectra. Limited resolution is a particular problem in proton NMR experiments, resulting in part from the limited proton chemical shift range (similar to 10 ppm) but even more from the splittings due to scalar coupling to nearby protons. Pure shift NMR spectroscopy (also known as broadband homonuclear decoupling) has been developed for disentangling overlapped proton NMR spectra. The resulting spectra are considerably simplified as they consist of single lines, reminiscent of proton-decoupled C-13 spectra at natural abundance, with no multiplet structure. The different approaches to obtaining pure shift spectra are reviewed here and several applications presented. Pure shift spectra are especially useful for highly overlapped proton spectra, as found for example in reaction mixtures, natural products and biomacromolecules. (C) 2015 The Author. Published by Elsevier B.V.
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